Overcoming challenges to enable targeting of metastatic breast cancer tumour microenvironment with nano-therapeutics: Current status and future perspectives

Tumour-microenvironment (TME) comprising of impenetrable inter-communications among stromal cells, tumour cells, cancer-associated blood and lymphatic vessels, pericytes, cancer-associated-fibroblasts, cancer-stem cells and extracellular matrix (ECM) that can substantially impact the onset, spread and progression of cancer metastasis.Metastatic bre

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A Megasecopteron From Upper Carboniferous Strata in Spain

In 1962 Professor F.Stockmans, of the Institut Royal des Sciences Naturelles de Belgique, kindly Kitchen sent me for study two insects from Upper Carboniferous deposits in Northern Spain.One of these (no.94.837), from the Mine de Poleiro, is part of a cockroach tegmen, which cannot be placed with certainty even to family level.The other specimen (n

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Different models for the Neolithisation of Albania

According to the archaeological evidence, the Neolithisation process in Albania seems to have passed through three Good Night different phases, with chronological gaps between them.The earliest phase is represented at the Vlusha site, where coarse monochrome pottery was found in the same layer as microlithic tools.The second phase can be traced bac

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